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[121] Persistent consumers may perhaps lose their urge for food and might experience severe malnutrition and substantial weight loss.
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copyright binds tightly on the dopamine transporter forming a posh that blocks the transporter's function. The dopamine transporter can no longer complete its reuptake function, and thus dopamine accumulates within the synaptic cleft. The amplified concentration of dopamine during the synapse activates write-up-synaptic dopamine receptors, that makes the drug satisfying and encourages the compulsive utilization of copyright.[one hundred ten]
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